Reprinted from the Journal of the American Medical Association Nov. 11, 1911, Vol. LVII.
|Statement||John F. Anderson and Joseph Goldberger.|
|Contributions||Goldberger, Joseph, 1874-1929.|
|The Physical Object|
higher when measles occurs prior to the second year of life.4 The average incubation period for measles is 11–12 days,5 and the average interval between exposure and rash onset is 14 days, with a range of 7–21 days.1, 6 Persons with measles are usually considered infectious. Measles is an acute viral infectious disease. References to measles can be found from as early as the 7th century. The. disease was described by the Persian physician Rhazes in the 10th century as “more to be dreaded than smallpox.” In , Peter Panum described the incubation period of measles and lifelong immunity after recovery from the. Manual for the laboratory diagnosis of measles and rubella virus infection, 3rd edition, June from the World Health Organization (WHO) This manual provides information about the WHO Global Measles and Rubella Laboratory Network. It contains detailed protocols for collection and handling of. -However, WHO estimated that, in , 45 million cases of measles and million measles-related deaths still occurred, increased to 82% -Two doses .
The Infectivity of the Secretions and Desquamating Scales of Measles, J. A. M. A. ((Nov. 11)) Recent Advances in Our Knowledge of Measles, Am. J. Dis. Child. 4: 20 ((July)) Serologic confirmation of measles infection depends on a fourfold rise in antibody titer between acute-phase and convalescent-phase sera (where the second serum sample is collected at least 10 days after the first, acute sample) or on demonstration of measles specific IgM antibody in a single serum specimen drawn between 1 and 2 weeks after the onset of rash. • Measles infection during pregnancy→ spontaneous abortion, LBW, premature delivery • Atypical Measles Syndrome: high fever, pneumonia, pleural effusion, edema of hands & feet, hepatic abn, unusual rash ↓ seen in persons who received killed measles vaccine in the past & who were subsequently exposed to measles virus While it has been quite the general belief for years that the infection of measles is contained in the blood and in the nasal and buccal secretions and, perhaps, in the "scales," it is surprising on what inconclusive data this belief has been us to the data as to the infectivity .
Measles is highly contagious; the attack rate in a susceptible individual exposed to measles is 90 percent. The period of contagiousness is estimated to be from five days before the appearance of rash to four days afterward. Infectious droplets from the respiratory secretions of a patient with measles can remain airborne for up to two hours. MEASLES IN INDIA • Major cause of childhood mortality and morbidity • 2% of under 5 mortality in India • Most cases in tribal and remote areas go unreported • Incidence is steadily declining RNA paramyxovirus 6 months To 3 years Seasonal trend Measles Period of infectivity -infection is transferred during childbirth when infected vaginal secretions and membranes come in contact with the newborn. Congenital infection is an infectious disease passed from mother to newborn. Atypical measles was seen in those who received the vaccine before and those in whom the immunization had not succeeded. In atypical measles the rash will spread from the extremities inward and petechiae, vesicles and papules can occur. Cough .